According to new research, Google is working on a new Bluetooth tracker device to compete with Apple's AirTags. 9to5Google reports: Since 2021, Google has included ultra-wideband (UWB) connectivity in its high-end "Pro" phones like the Pixel 6 Pro and Pixel 7 Pro. For now, the hardware has only been used for niche cases like unlocking a luxury car or sending files to a friend, but it's been clear that Google intends for UWB to be used more often. [...] To build up its own "Finder Network," compete with Apple AirTags, and potentially make UWB more useful on Pixel phones, Google is reportedly developing its own tracking accessory. The information comes courtesy of Android researcher and frequent Pixel leaker Kuba Wojciechowski.

The tracker is said to be in development under the codename "Grogu" -- a reference to the popular Star Wars series "The Mandalorian" -- alongside the alternate names "GR10" and "Groguaudio." The only other tidbits that have been uncovered so far suggest that the Nest team is seemingly taking lead on the development and that the tracker may be available in multiple colors. The "Groguaudio" codename suggests that Google's tracker would potentially come equipped with a speaker. On Apple's AirTags, a built-in speaker serves as both a privacy measure and a location aid, as if you move someone else's AirTag after it's been separated from them, it will beep. This is just one of many potential privacy issues that Google will need to work through before launching a tracker accessory like this one.

Russia's attacks on Ukraine's electrical grid are straining the war-torn country's mobile-telephone network, leading to a global hunt for batteries and other equipment critical for keeping the communications system working. From a report: Ukraine's power outages aren't just putting out the lights. The electricity shortages also affect water supplies, heating systems, manufacturing and the cellular-telephone and internet network, a vital communications link in a nation where fixed-line telephones are uncommon. Consumers can charge their cellphones at cafes or gas stations with generators, but the phones have to communicate with base stations whose antennas and switching equipment need large amounts of power. With rolling blackouts now a regular feature of life in Ukraine, the internet providers are relying on batteries to keep the network going.

The stakes are high, since Ukrainian officials are using positive news of the war, speeches by President Volodymyr Zelensky and videos distributed by cellphone to maintain popular support for fighting Russia. First responders and evacuees rely on the mobile network, and a long-term loss of communications in major cities would compound the existing problems of electrical, heating and water outages, the companies say. Labor shortages have exacerbated the mobile-network issues as many Ukrainians have been displaced by the war or gone to the front to fight. In December, the chief executive of Ukraine's Lifecell mobile operator, Ismet Yazici, went into the field himself to wheel in a generator and restore backup power at a cell tower, according to the company. But the biggest problem is power equipment.

The Verge reports "undeniable momentum" for Matter, the royalty-free interoperability standard that "allows smart home devices from any manufacturer to talk to other devices directly and locally with no need to use the cloud."

"Matter was the buzzword throughout CES 2023 this year, with most companies even remotely connected to the smart home loudly discussing their Matter plans." The new smart home standard was featured in several keynotes and displayed prominently in smart home device makers' booths as well as in Google, Amazon, and Samsung's big, showy displays. More importantly, dozens of companies and manufacturers announced specific plans. Several companies said they would update entire product lines, while others announced new ones, sometimes with actual dates and prices. And Matter controllers have become a major thing, with at least four brand-new ones debuting at CES. Interestingly, nearly all of them have a dual or triple function, helping banish the specter of seemingly pointless white hubs stuck in your router closet....

Matter works over the protocols Thread, Wi-Fi, and ethernet and has been jointly developed by Apple, Google, Samsung, Amazon, and pretty much every other smart home brand you can name, big or small. If a device supports Matter, it will work locally with Amazon Alexa, Samsung SmartThings, Apple Home, Google Home, and any other smart home platform that supports Matter. It will also be controllable by any of the four voice assistants....

The big four have turned on Matter support on their platforms, but Amazon's approach has been piecemeal, and aside from Apple, nobody supports onboarding devices to Matter on iOS yet.

However, that is shifting: at CES, Amazon announced a full rollout by spring, and Samsung's Jaeyeon Jung told The Verge that Matter support is coming to its iOS app this month. There's still no news on Matter support in Google Home's iOS app. Then there's the whole competing Thread network issue, although that sounds like it will be resolved sooner rather than later....

The Matter device drought should be over soon — although, judging by most of these ship dates, not until at least the second half of 2023.
"It's also likely we'll see dedicated bridges coming out that can bring Z-Wave and other products with proprietary protocols into Matter...."

"Thousands of CES 2023 attendees tested out the Las Vegas Convention Center Loop tunnel transit system," reports Fierce Electronics, "for quick 1.7-mile trips offering them a prelude of more of the efficient tunnels to come." The service was free during the early January event, offering 115,000 CES attendees a chance to reduce a 45-minute LVCC cross-campus walk time down to 2 minutes, not including short waits for Tesla vehicles with drivers. "I call shotgun!" one gleeful CES attendee said while waiting in line. Once inside the white Tesla vehicle, the man used his phone to video the entire trip, marking its sudden acceleration to maximum speed in the single lane white tunnel, an experience the design engineer likened to a slick amusement park ride over a tunnel race track....

Construction is expected to begin in 2023 on the 29-mile Vegas Loop tunnel network approved by the county in 2021 to ultimately connect 51 stations throughout the resort corridor. In 2022, the city of Las Vegas unanimously approved bringing the Vegas Loop to city limits, which increases the system to 34 miles and 55 stations in all.

The dream is for Vegas Loop to eventually connect to Los Angeles, a distance of 270 miles.

Phoronix reports: With the next Linux kernel cycle we could see upstream disable their driver support for Microsoft's Remote Network Driver Interface Specification (RNDIS) protocol due to security concerns.

RNDIS is the proprietary protocol used atop USB for virtual Ethernet functionality. The support for RNDIS outside of Microsoft Windows has been mixed. RNDIS isn't widely used today in cross-platform environments and due to security concerns the upstream Linux kernel is looking to move the RNDIS kernel drivers behind the "BROKEN" Kconfig option so they effectively become disabled in future kernel builds.

Ultimately once marked as "BROKEN" for a while, the drivers will likely be eventually removed from the upstream source tree.
Greg Kroah-Hartman wrote in a commit: "The Microsoft RNDIS protocol is, as designed, insecure and vulnerable on any system that uses it with untrusted hosts or devices. Because the protocol is impossible to make secure, just disable all rndis drivers to prevent anyone from using them again."

It was meant to be the first-ever orbital mission to take off from the United Kingdom — carried by a Virgin Orbit rocket launched from a private jumbo jet Monday over the Atlantic ocean, according to the BBC.

But instead "at an altitude of approximately 180km (111 miles), the upper stage experienced an anomaly which 'prematurely ended' the first burn. The company said this event ended the mission, with the rocket components and payload falling back to Earth within the approved safety corridor.,,,"

At this point the unmanned rocket became "a slow moving fireball in the sky," astrodynamics lecturer Marco Langbroek told Gizmodo in an email. The rocket's hellish descent was captured on video, revealing the unfortunate journey back from space. Ramón López, an observer at the Spanish Meteor Network, caught the rocket reentering Earth's atmosphere from Lanzarote, one of the Canary Islands off the west coast of Africa. He released the footage on YouTube, as well as on Twitter.
Earlier this week Space.com noted that four previous Virgin Orbit missions have all been successful, deploying a total of 33 satellites into orbit.

Last month, The Guardian closed its offices after being hit by a "highly sophisticated" ransomware attack. In an update to staff, Guardian group chief Anna Bateson and newspaper editor-in-chief Katharine Viner said intruders were able to access the personal data of UK employees. Engadget reports: They described the incident as a "highly sophisticated cyber-attack involving unauthorised third-party access to parts of our network," most likely triggered by a "phishing" attempt in which the victim is tricked, often via email, into downloading malware. The Guardian said it had no reason to believe the personal data of readers and subscribers had been accessed. It is not believed that the personal data of Guardian US and Guardian Australia staff has been accessed either. However, the message to staff said there had been no evidence of data being exposed online, so the risk of fraud is considered to be low.

The attack was detected on 20 December and affected parts of the company's technology infrastructure. Staff, most of whom have been working from home since the attack, have been able to maintain production of a daily newspaper, while online publishing has been unaffected. The Guardian has been using external experts to gauge the extent of the attack and to recover its systems. Although the Guardian expects some critical systems to be back up and running "within the next two weeks," a return to office working has been postponed until early February in order to allow IT staff to focus on network and system restoration.

The number of active users on the Mastodon social network has dropped more than 30% since the peak and is continuing a slow decline, according to the latest data posted on its website. There were about 1.8 million active users in the first week of January, down from over 2.5 million in early December. The Guardian reports: Mastodon, an open-source network of largely independently hosted servers, has often been touted as an alternative to Twitter. And its growth appears connected to controversies at Twitter. But for many it doesn't fulfill the role that Twitter did and experts say it may be too complicated to really replace it. [...]

There were about 500,000 active Mastodon users before Elon Musk took control of Twitter at the end of October. By mid-November, that number climbed to almost 2 million active users. [...] The surge in new Mastodon users continued throughout November, peaking at over 130,000 new users a day. The upticks often coincided with controversial decisions made by Elon Musk. Data from Google suggests there was also a surge in searches for Mastodon in April 2022, around the time Musk announced he had become Twitter's largest shareholder.

"Twitter, in its most basic form is simple," Meg Coffey, a social media strategist, said. "You can open up an app or open up a website, type some words, and you're done. I mean, it was [a] basic SMS platform." For many, Mastodon may have proved too hard to port over their communities and was just too complicated. Some may have gone back to Twitter, while others, said Coffey, may have dropped social media entirely. "Everybody went and signed up [on Mastodon] and realized how hard it was, and then got back on Twitter and were like, 'Oh, that's, that's hard. Maybe we won't go there,'" she said. "It's like the people that said 'I'm moving to Canada' when Donald Trump was elected," Coffey added. "They never actually moved to Canada."

"More than half a million people who deposited money with collapsed crypto lender Celsius Network have been dealt a major blow to their hopes of recovering their funds," reports the Washington Post, "with the judge in the company's bankruptcy case ruling that the money belongs to Celsius and not to the depositors." The judge, Martin Glenn, found that Celsius's terms of use — the lengthy contracts that many websites publish but few consumers read — meant "the cryptocurrency assets became Celsius's property."

The ruling underscores the Wild West nature of the unregulated crypto industry. On Thursday, New York Attorney General Letitia James moved to impose a kind of order, or at least legal repercussions, on Celsius founder Alex Mashinsky, whom she accused in a lawsuit of defrauding hundreds of thousands of consumers.... And while Glenn's ruling won't affect FTX, whose terms of use were different, some analysts saw the ruling as spreading beyond Celsius.

"There are many other platforms that feature terms of use that are similar to Celsius's," said Aaron Kaplan, a lawyer with the financial-focused firm of Gusrae Kaplan Nusbaum and co-founder of his own crypto company. Customers need to "understand the risks that they are taking when depositing their assets onto insufficiently regulated platforms," he said.

An anonymous reader quotes a report from CNBC: A new law that went into effect this week requires most California employers to disclose salaries on job listings. The law affects every company with more than 15 employees looking to fill a job that could be performed from the state of California. It covers hourly and temporary work, all the way up to openings for highly paid technology executives. That means it's now possible to know the salaries top tech companies pay their workers. For example: A program manager in Apple's augmented reality group will receive base pay between $121,000 and $230,000 per year, according to an Apple posting Wednesday. A midcareer software engineer at Google Health can expect to make between $126,000 and $190,000 per year. A director of software engineering at Meta leading teams building network infrastructure will make at least $253,000 and as much as $327,000 in salary per year. Notably, these salary listings do not include any bonuses or equity grants, which many tech companies use to attract and retain employees.

California's pay transparency law is intended to reduce gender and race pay gaps and help minorities and women better compete in the labor market. For example, people can compare their current pay with job listings with the same job title and see if they're being underpaid. [...] But the new disclosures under the law might not tell the whole story of what a job pays. Companies can choose to display wide pay ranges, violating the spirit of the law, and the law doesn't require companies to reveal bonuses or equity compensation. The law could also penalize ambitious workers who are gunning for more money because of their experience or skills, the California Chamber of Commerce said last year when opposing the bill. Some employers might be wary of posting pay to prevent bidding wars for top talent.

There are two primary components to California Senate Bill No. 1162, which was passed in September and went into effect Jan. 1. First is the pay transparency component on job listings, which applies to any company with more than 15 employees if the job could be done in California. The second part requires companies with more than 100 employees to submit a pay data report to the state of California with detailed salary information broken down by race, sex and job category. Companies have to provide a similar report on the federal level, but California now requires more details. Employers are required to maintain detailed records of each job title and its wage history, and California's labor commissioner can inspect those records. California can enforce the law through fines and can investigate violations. The reports won't be published publicly under the new law.

Qualcomm has announced that its new processors and modems will allow phones to communicate with the Iridium satellite network, letting users send and receive messages even in areas without cell coverage. The Verge reports: The feature, called Snapdragon Satellite, will be available in phones that have both Qualcomm's Snapdragon 8 Gen 2 processor and its X70 Modem system, along with some additional radios. Phones that support it should be "launched in select regions starting in the second half of 2023," according to the company's press release, and there are several manufacturers working on designs, according to Francesco Grilli, a Qualcomm spokesperson who helped conduct a briefing for journalists. For now, the feature will likely only be available in flagship Android phones, as Qualcomm's only including the tech in its premium chips. Companies that want to add it to their phones will work directly with Qualcomm to figure out the software and hardware, but they shouldn't have to build new relationships with Iridium, according to Grilli. To the satellites, phones with the tech will look like any other Iridium-enabled devices. As for who will pay for the messages, "the cost of the satellite-based messaging service and dependent services will depend on OEMs and service providers and how they choose to offer the service," according to Grilli.

At first, Snapdragon Satellite will be limited to use in emergency situations, letting you contact someone for help even if you're in a remote area without cell service. According to Grilli, "Snapdragon Satellite leverages Garmin Response." When you send an SOS, "response coordinators immediately see the customer's Latitude/Longitude in their proprietary mapping and response coordination software to determine the appropriate agency to coordinate the rescue." Qualcomm says that, eventually, it'll support "premium messaging," which will likely cost extra and will have to be implemented by OEMs, cell carriers, or other over-the-top service providers. So far, this isn't something Apple offers; you can only send texts via satellite using its SOS feature.

While Qualcomm says the emergency service will be free or very cheap, it hasn't provided details yet on how much it'll cost you if you just want to be able to text your friends from remote areas, like a hiking trail, ski lift, or even a boat in the middle of the ocean. Once that service becomes available, however, Qualcomm says you'll be able to use it with your regular phone number. (That likely won't be the case for emergency use, but it matters less there.) [...] While details are sparse on what it'll be like to actually send and receive satellite messages, it sounds like the experience will be similar to Apple's in that you'll have to follow instructions on your phone to point it toward a satellite. According to Grilli, your phone will be able to predict where Iridium's satellites are months in advance thanks to the way its constellation orbits the Earth. When you go to connect to one, it'll use GPS and other measurements to determine where you need to be facing...

An anonymous reader quotes a report from Ars Technica: On Thursday, Mercedes-Benz announced that it is entering the DC fast-charging arena for electric vehicles. The German automaker is in the midst of an electrification push and a plan to be carbon-neutral by 2039, and it evidently doesn't believe that the current charging infrastructure is as good as its new EVs, so it's doing something about the situation. Mercedes says it plans to deploy more than 10,000 fast chargers around the world, starting in North America. The new network is separate from and independent of Ionity, the European fast-charging network backed by Mercedes, BMW, Ford, and Volkswagen. Here in the US, Mercedes is partnering with the charging company ChargePoint and MN8 Energy, a solar and battery-storage company. Together, they will deploy more than 2,500 DC fast chargers at more than 400 sites around the US by 2027.

The chargers will feature plug-and-charge compatibility and won't be restricted to Mercedes' EVs. Mercedes also says the locations and surroundings will be carefully chosen -- all too often, banks of DC chargers are located in desolate and lonely corners of mall parking lots that can make charging at night a stressful experience for some drivers. So the OEM plans to build the chargers "with food outlets and restrooms situated nearby." It also says there will be surveillance cameras and other security in place to provide "a safe and secure charging environment." Expect a minimum of four DC chargers at each hub, similar to an Electrify America charging location. But some hubs will have as many as 12 chargers, and there are plans for as many as 30 in some locations. The hubs will use ChargePoint's modular Express Plus system, which is capable of up to 500 kW per charging port, although Mercedes says that chargers will be "up to 350 kW" in power. And load management will ensure that if multiple EVs are charging at the same time, one charger doesn't end up throttling the rest.

In keeping with the company's 2039 sustainability goals, the electricity it uses will come from green energy suppliers or come with renewable energy certificates. Some hubs will use solar to power the lighting and security cameras. None of this will be particularly cheap. In fact, the initiative will cost more than $1.1 billion (1 billion euro) over the next six or seven years, with the costs split evenly between Mercedes and MN8 Energy. And this is just the start -- plans for more charger deployment in Europe and China will be announced in the future.

New York's attorney general on Thursday filed a civil lawsuit accusing Celsius Network founder Alex Mashinsky of scheming to defraud hundreds of thousands of investors by inducing them to deposit billions of dollars in digital assets with his cryptocurrency company. From a report: The lawsuit filed in a New York state court in Manhattan accuses Mashinsky of violating the state's Martin Act, which gives Attorney General Letitia James broad power to pursue civil and criminal cases over securities fraud, and other laws. Mashinsky was accused of promoting Celsius as a safe alternative to banks, while concealing that Celsius was actually engaged in risky investment strategies that contributed to its collapse and bankruptcy. "Alex Mashinsky promised to lead investors to financial freedom but led them down a path of financial ruin," James said in a statement. "Making false and unsubstantiated promises and misleading investors is illegal."

The collapse of crypto exchange FTX sparked a run on Silvergate Capital, forcing the bank to sell assets at a steep loss to cover some $8.1 billion in withdrawals. From a report: Crypto-related deposits plunged 68% in the fourth quarter, the bank said in an early release of some quarterly results. To satisfy the withdrawals, Silvergate liquidated debt it was holding on its balance sheet. The $718 million it lost selling the debt far exceeds the bank's total profits since at least 2013. The bank has laid off 40% of its staff, or about 200 employees, and said it would pare back its businesses. It shelved a plan to launch its own digital currency, writing off $196 million it spent buying the technology that Facebook had built in its failed attempt to start a crypto-based payments network. Silvergate caters to companies in the crypto business, taking their deposits and operating a network that links investors to crypto exchanges.

FTX and other companies controlled by its founder, Sam Bankman-Fried, accounted for about $1 billion of the bank's deposits. Silvergate was able to survive such a steep decline in deposits because it isn't structured like most banks. It sold off much of its traditional banking operations and branches to focus on providing bank accounts to crypto exchanges and investors. Crypto-related deposits account for some 90% of the bank's total, and it keeps almost all of its deposits in cash or easy-to-sell securities. The bank said it remains committed to crypto and has the funding to handle a "sustained period of transformation."

A group representing internet service providers across Europe said on Tuesday that a proposal to make Big Tech companies pay towards telecom operators' network costs could create systemic weakness in critical infrastructure. From a report: Telecom operators have been pushing the European Union to implement new laws that would see U.S. tech firms like Alphabet's Google, Meta's Facebook, and Netflix bear some of the costs of Europe's telecoms network, arguing that they drive much of the region's internet traffic.

In September, European Commission's industry chief Thierry Breton said he would launch a consultation on so-called "fair share" payments in early 2023, before proposing legislation. Now, the European Internet Exchange Association said the proposals risked reducing the quality of service for internet users across Europe, and could "accidentally create new systemic weaknesses" in critical infrastructure, in a letter addressed to the European Commission's industry chief Thierry Breton and the Executive Vice President Margrethe Vestager.

The Southwest Airlines meltdown that stranded thousands of passengers during one of the busiest travel weeks of the year exposed a major industry shortcoming: crew-scheduling technology that was largely built for a bygone era and is due for a major overhaul. From a report: Southwest relies on crew-assignment software called SkySolver, an off-the-shelf application that it has customized and updated, but is nearing the end of its life, according to the airline. The program was developed decades ago and is now owned by General Electric. During the winter storm, amid a huge volume of changes to crew schedules to work through, SkySolver couldn't handle the task of matching crew members and which flights they should work, executives of the Dallas-based carrier said.

Southwest's software wasn't designed to solve problems of that scale, Chief Operating Officer Andrew Watterson said Thursday, forcing the airline to revert to manual scheduling. Unlike some large rivals with hub-and-spoke networks, Southwest planes hopscotch from city to city, which may have been another complicating factor. Many carriers still rely on homegrown solutions, which largely were built on legacy mainframe computers, analysts say. Analysts and industry insiders say the airline industry is overdue for a massive technology overhaul that would take advantage of highly scalable cloud technologies and fully connect disparate sources of real-time data to better coordinate crews with aircraft. The airline sector has been among the slowest to adopt cloud-based and analytics technologies that could help solve complicated transportation network problems, those analysts say.

India set an "incredibly important precedent" by banning TikTok two and a half years ago, FCC Commissioner said, as he projected a similar fate for the Chinese giant Bytedance app in the U.S. From a report: Brendan Carr, Commissioner of the FCC, warned that TikTok "operates as a sophisticated surveillance tool," and told the Indian daily Economic Times that banning the social app is a "natural next step in our efforts to secure communication network."

The senior Republican on the Federal Communications Commission said he is worried that China could use sensitive and non-public data gleaned from TikTok to "blackmail, espionage, foreign influence campaigns and surveillance." He said: "We need to follow India's lead more broadly to weed out other nefarious apps as well," he said. Carr's remarks further illustrates a growing push among U.S. states and lawmakers that are increasingly growing cautious of TikTok, which has amassed over 100 million users in the nation.

Fierce Wireless reports: Verizon is telling customers that if they're still using a 3G CDMA or 4G (non-VoLTE) phone that does not support its newer network technologies, "your line will be suspended without billing and will lose the ability to call, text, or use data."

Verizon is the last of the Big 3 wireless carriers in the U.S. to shut down a 3G network and repurpose the spectrum for newer technology. AT&T was first, shutting its 3G network down in February. T-Mobile's shuttered its 3G network over the summer.... Verizon has been working with customers — both consumers and businesses — since 2016 to ensure customers have "every opportunity" to get a device that uses either 4G or 5G, including direct outreach to customers and even sending some customers updated devices proactively, according to Karen Schulz of Verizon's Global Network & Technology Communications team.

Indeed, the company initially said it was closing its 3G network in 2019. Then they extended it to the end of 2020 and finally, to the end of 2022. In March 2021, Verizon made it clear they were sticking with the 2022 end date and advised customers still accessing the 3G network that they may experience a degradation or complete loss of service.
"Even after that, until the day before their February billing cycle, they'll still be able to use the phones for two things: calling 911 and Verizon customer service," reports the Verge: While 3G will still exist in other countries for quite a few more years, Verizon's deadline is pretty much the end of the line for it here in the US. The tech hasn't gone gentle into that good night; carriers delayed their shutdowns several times, there were tiffs between Dish and T-Mobile, and you can't just turn a network that had been around for years off without things starting to break. (Some notable examples: some connected cars and trucks have been pushed offline, as have parking meters and older Kindles. AT&T's shutdown was even blamed for delays in reporting voting results in Michigan this year.)

Part of the reason carriers are decommissioning their networks is to help build their new ones. As we saw earlier this month, T-Mobile's latest and greatest 5G tech makes use of spectrum that was once part of its 3G network.
The Verge's conclusion? "Spare a thought for the tech that helped build the mobile-first world we live in; even if this ends up being the last time you ever think about it."

Long-time geriatrician James Kirkland is a Mayo clinic researcher joining "a growing movement to halt chronic disease by protecting brains and bodies from the biological fallout of aging," reports Ars Technica.

"While researchers like Kirkland don't expect to extend lifespan, they hope to lengthen 'health span,' the time that a person lives free of disease." One of their targets is decrepit cells that build up in tissues as people age. These "senescent" cells have reached a point — due to damage, stress or just time — when they stop dividing, but don't die. While senescent cells typically make up only a small fraction of the overall cell population, they accounted for up to 36 percent of cells in some organs in aging mice, one study showed. And they don't just sit there quietly. Senescent cells can release a slew of compounds that create a toxic, inflamed environment that primes tissues for chronic illness. Senescent cells have been linked to diabetes, stroke, osteoporosis and several other conditions of aging.

These noxious cells, along with the idea that getting rid of them could mitigate chronic illnesses and the discomforts of aging, are getting serious attention. The U.S. National Institutes of Health is investing $125 million in a new research effort, called SenNet, that aims to identify and map senescent cells in the human body as well as in mice over the natural lifespan. And the National Institute on Aging has put up more than $3 million over four years for the Translational Geroscience Network multicenter team led by Kirkland that is running preliminary clinical trials of potential antiaging treatments. Drugs that kill senescent cells — called senolytics — are among the top candidates. Small-scale trials of these are already underway in people with conditions including Alzheimer's, osteoarthritis and kidney disease.

"It's an emerging and incredibly exciting, and maybe even game-changing, area," says John Varga, chief of rheumatology at the University of Michigan Medical School in Ann Arbor, who isn't part of the Translational Geroscience Network. But he and others sound a note of caution as well, and some scientists think the field's potential has been overblown. "There's a lot of hype," says Varga. "I do have, I would say, a very healthy skepticism." He warns his patients of the many unknowns and tells them that trying senolytic supplementation on their own could be dangerous....

So far, evidence that destroying senescent cells helps to improve health span mostly comes from laboratory mice. Only a couple of preliminary human trials have been completed, with hints of promise but far from blockbuster results.
In conjunction with SpaceX and Axiom Space, Kirkland and a colleague also are investigating how space radiation affects senescence indicators in astronauts, the article points out . "They hypothesize that participants in future long-term missions to Mars might have to monitor their bodies for senescence or pack senolytics to stave off accelerated cellular aging caused by extended exposure to radiation."

A Boston Globe tech reporter checked last year's performance for the region's tech companies: A list of the worst local performers includes some truly bottom-of-the-barrel returns. Cannabis tech company Agrify in Billerica suffered a 99.6 percent stock drop in 2022. Wireless Internet service Starry and diet-device maker Gelesis were close behind with losses of 99.5 and 99.3 percent, respectively. (All stock prices are as of Dec. 28.)

Agrify suffered a recent sales drop and growing losses while ending the year facing a customer lawsuit and possible hostile takeover. Starry was unable to raise the funds needed to continue building its network and put itself up for sale last month. And Gelesis fell far short of its sales forecast, bringing in about $30 million of revenue compared to a projection of $171 million presented when its merger with Capstar Special Purpose Acquisition Corp. was announced in 2021....

Companies like Starry and Gelesis that went public by merging with blank-check firms had a particularly tough year, as investors flipped from euphoria to panic on the so-called SPAC boom. The average 2022 return for 21 such stocks tracked by the Globe was a loss of 70 percent. Of tech companies that went public the traditional way, the average loss was 45 percent. Toast, which did a standard IPO at the same time Ginkgo Bioworks completed its SPAC deal, lost 51 percent for the year while Ginkgo plunged 80 percent.
In the wider market of tech stocks, the article notes that the S&P 500 index dropped 20%, while the Nasdaq Composite plunged 34 percent, "and tech giants such as Apple, Amazon, and Meta shed hundreds of billions of dollars of market value."

"Of 60 local tech stocks tracked by the Globe, only two posted positive returns: robotics maker Symbotic in Wilmington and payments company WEX in Portland, Maine.... Perhaps in 2023, the winners column will be a little longer."