Nature magazine reports that "A study that stoked enthusiasm for the now-disproven idea that a cheap malaria drug can treat COVID-19 has been retracted — more than four-and-a-half years after it was published." Researchers had critiqued the controversial paper many times, raising concerns about its data quality and an unclear ethics-approval process. Its eventual withdrawal, on the grounds of concerns over ethical approval and doubts about the conduct of the research, marks the 28th retraction for co-author Didier Raoult, a French microbiologist, formerly at Marseille's Hospital-University Institute Mediterranean Infection (IHU), who shot to global prominence in the pandemic. French investigations found that he and the IHU had violated ethics-approval protocols in numerous studies, and Raoult has now retired.

The paper, which has received almost 3,400 citations according to the Web of Science database, is the highest-cited paper on COVID-19 to be retracted, and the second-most-cited retracted paper of any kind....

Because it contributed so much to the HCQ hype, "the most important unintended effect of this study was to partially side-track and slow down the development of anti-COVID-19 drugs at a time when the need for effective treatments was critical", says Ole Søgaard, an infectious-disease physician at Aarhus University Hospital in Denmark, who was not involved with the work or its critiques. "The study was clearly hastily conducted and did not adhere to common scientific and ethical standards...."

Three of the study's co-authors had asked to have their names removed from the paper, saying they had doubts about its methods, the retraction notice said.
Nature includes this quote from a scientific-integrity consultant in San Francisco, California. "This paper should never have been published — or it should have been retracted immediately after its publication."

"The report caught the eye of the celebrity doctor Mehmet Oz," the Atlantic reported in April of 2020 (also noting that co-author Raoult "has made news in recent years as a pan-disciplinary provocateur; he has questioned climate change and Darwinian evolution...")

And Nature points out that while the study claimed good results for the 20 patients treated with HCQ, six more HCQ-treated people in the study actually dropped out before it was finished. And of those six people, one died, while three more "were transferred to an intensive-care unit."

Thanks to Slashdot reader backslashdot for sharing the news.

sciencehabit shares a report from Science Magazine: With a few keystrokes, anyone can ask an artificial intelligence (AI) program such as ChatGPT to write them a term paper, a rap song, or a play. But don't expect William Shakespeare's originality. A new study finds such output remains derivative -- at least for now. [...] [O]bjectively testing this creativity has been tricky. Scientists have generally taken two tacks. One is to use another computer program to search for signs of plagiarism -- though a lack of plagiarism does not necessarily equal creativity. The other approach is to have humans judge the AI output themselves, rating factors such as fluency and originality. But that's subjective and time intensive. So Ximing Lu, a computer scientist at the University of Washington, and colleagues created a program featuring both objectivity and a bit of nuance.

Called DJ Search, it collects pieces of text of a minimum length from whatever the AI outputs and searches for them in large online databases. DJ Search doesn't just look for identical matches; it also scans for strings whose words have similar meanings. To evaluate the meaning of a word or phrase, the program itself relies on a separate AI algorithm that produces a set of numbers called an "embedding," which roughly represents the contexts in which words are typically found. Synonymous words have numerically close embeddings. For example, phrases that swap "anticipation" and "excitement" are considered matches. After removing all matches, the program calculates the ratio of the remaining words to the original document length, which should give an estimate of how much of the AI's output is novel. The program conducts this process for various string lengths (the study uses a minimum of five words) and combines the ratios into one index of linguistic novelty. (The team calls it a "creativity index," but creativity requires both novelty and quality -- random gibberish is novel but not creative.)

The researchers compared the linguistic novelty of published novels, poetry, and speeches with works written by recent LLMs. Humans outscored AIs by about 80% in poetry, 100% in novels, and 150% in speeches, the researchers report in a preprint posted on OpenReview and currently under peer review. Although DJ Search was designed for comparing people and machines, it can also be used to compare two or more humanmade works. For example, Suzanne Collins's 2008 novel The Hunger Games scored 35% higher in linguistic originality than Stephenie Meyer's 2005 hit Twilight. (You can try the tool online.)

Axiom Space has revised its plan for assembling its commercial space station by launching the Payload, Power, and Thermal module first, enabling it to operate as a free-flying platform as early as 2028 -- two years ahead of the original timeline. Space.com reports: NASA awarded Axiom Space a contract in 2020 to attach one or more modules to the International Space Station (ISS), which is set to retire by 2030 at the earliest. The original plan called for Axiom to detach a multi-module group from the ISS, creating a commercial outpost in low Earth orbit that will continue operating after the ISS is gone. But that plan has now been altered.

To create its space station, Axiom plans to launch five modules: a payload/power/thermal element, an airlock, a research/manufacturing hub, and a pair of habitat modules. The original plan was for Axiom to launch the Habitat 1 module to the ISS first, followed by the additional elements. The new assembly sequence will see the Payload, Power and Thermal module launch to the ISS first. This module could detach from the station -- and become a free flyer called Axiom Station -- as soon as 2028, according to the company. After that happens, Axiom will continue assembling the outpost, launching the Habitat 1 module to meet up with it. Habitat 1 will be followed by the airlock, the Habitat 2 module, and then the research and manufacturing facility. Angela Hart, a manager for the Commercial Low Earth Orbit Development Program at NASA's Johnson Space Center in Houston, said: "The updated assembly sequence has been coordinated with NASA to support both NASA and Axiom Space needs and plans for a smooth transition in low Earth orbit."

NASA's Parker Solar Probe will make its closest approach yet to the Sun on Christmas Eve, flying within 3.8 million miles of the solar surface and entering its atmosphere for the first time.

The spacecraft, which travels at speeds up to 430,000 miles per hour, aims to study the origins of solar wind -- the stream of charged particles emanating from the Sun's corona. The probe's heat shield will endure temperatures exceeding 2,500-degree Fahrenheit during the flyby, requiring specialized materials like sapphire crystal tubes and niobium wiring to protect its instruments.

Ars Technica's Eric Berger reports: In a wide-ranging interview with a Russian television station, the chief executive of Russia's main space corporation said the country is now planning to participate in the International Space Station project all the way to NASA's desired goal of 2030. "In coordination with our American colleagues, we plan to de-orbit the station sometime around the beginning of 2030," the country's chief space official, Yuri Borisov, said during the interview. "The final scenario will probably be specified after the transition to a new NASA administration."

While the documents for such an extension have not been signed, these comments appear to represent a change in tone from Russia. When he first became head of Roscosmos in 2022, Borisov said Russia would leave the station partnership "after" 2024, which was interpreted as shortly thereafter. Later, Russia committed to working with NASA to keep the orbital outpost flying only through 2028. The US space agency has expressed a consistent desire to keep flying the station until 2030, after which point it hopes that private space station operators can provide one or more replacement facilities.
Borisov said the aging station, elements of which have now been in space for more than a quarter of a century, are becoming difficult to maintain. "Today our cosmonauts have to spend more time repairing equipment and less and less time conducting experiments," he said. Borisov also discussed Russia's challenges of getting private investment in space-related activities, saying: "In the West, particularly in America, 70 percent of space services are provided by satellite constellations created by private companies. This process has only just begun with us. This is a very risky business for potential investors."

"Right now, the dynamic growth of private space is being influenced by the general economic situation (likely referring to Russia's costly war in Ukraine), high inflation and interest rates, which leads to expensive money for private investors. We can hope that this will be a temporary period and more favorable times will come soon."

An anonymous reader quotes an opinion piece from The Guardian, written by Prof Mark Pallen and Dr Aimee Parker (Quadram Institute, Norwich), Prof Nick Loman (University of Birmingham), Prof Alan Walker (University of Aberdeen): Contrary to what is implied in [this article], the weight of expert opinion in medical microbiology rejects the existence of a "brain microbiome" in the sense of a resident microbial community in healthy human brains. While pathogenic microbes -- such as Borrelia burgdorferi, which causes Lyme disease, or fungal pathogens like Cryptococcus neoformans -- can invade the brain and cause neurological symptoms, these are examples of infections, not evidence of a native microbial community.

Similarly, cognitive benefits of vaccines can be explained by their role in preventing infections or modulating immune responses and inflammation, rather than any impact on a "brain microbiome." Furthermore, the studies cited in the article have not undergone independent validation, nor do they provide any kind of consistent picture. This mirrors controversies around other supposed microbiomes -- such as that of the placenta -- which have failed to withstand independent scrutiny. Over a decade of research indicates that contamination, typically from laboratory reagents, is the most plausible explanation for such findings, particularly when even supposedly ultrapure water has been shown to harbor DNA signatures and culturable microbes.

If diverse microbes are truly abundant in the brain, why have they not been repeatedly and consistently cultured in over a century and a half of medical microbiology? Why have they not been observed in numerous microscopy studies of human brain tissue? Efforts to explore overlooked roles of microbes in neurological conditions are welcome, but they must be grounded in robust and reproducible science -- not speculative discussion of a "brain microbiome." In the article mentioned above, author Amy Fleming discusses the emerging research connecting infections such as Borrelia, Cryptococcus, and herpes viruses to reversible dementia, challenging the long-held belief that the brain is sterile.

She highlights the Alzheimer's Pathobiome Initiative, which investigates how brain infections may contribute to diseases like Alzheimer's, with the goal of developing new diagnostic tools and treatments. Vaccines like BCG and zoster have shown protective effects, while good hygiene, oral health, and a healthy lifestyle can help reduce risks.

The publisher of a high-profile, now-corrected study on black plastics has been removed from a critical index of academic journals amid questions about quality criteria, according to a report by Retraction Watch. From a report: On December 16, Clarivate -- a scholarly publication analytics company -- removed the journal Chemosphere from its platform, the Web of Science, which is a key index for academic journals. The indexing platform tracks citations and calculates journal "impact factors," a proxy for relevance in its field. It's a critical metric not only for the journals but for the academic authors of the journal's articles, who use the score in their pursuit of promotions and research funding.

To be included in the Web of Science, Clarivate requires journals to follow editorial quality criteria. According to Retraction Watch, Chemosphere has retracted eight articles this month and published 60 expressions of concern since April. In a December 12 news release, Chemosphere acknowledged the quality concerns and laid out steps it will take to improve its editorial process. Those include improvements to article vetting and peer review, along with assurances that articles will be retracted if there's evidence of policy breaches. "We believe that these measures will help us regain the standard of research integrity that has always been so important to us," the news release stated.

NASA has delayed the launch of SpaceX Crew-10 to late March 2025 to allow time for processing a new Dragon spacecraft, extending the stay of astronauts Butch Wilmore and Suni Williams on the ISS to about nine months. CNN reports: Williams and Wilmore launched to space in June, piloting the first crewed test flight of Boeing's Starliner spacecraft. Their trip, expected to last about a week, ballooned into a monthslong assignment after their vehicle experienced technical issues en route to the space station and NASA determined it would be too risky to bring them home aboard the Starliner.

The astronauts have since joined Crew-9, a routine space station mission originally slated to return to Earth no earlier than February after a handoff period with Crew-10. Now, Crew-10 will get off the ground at least a month later than expected because NASA and SpaceX teams need "time to complete processing on a new Dragon spacecraft for the mission," according to the space agency. "NASA and SpaceX assessed various options for managing the next crewed handover, including using another Dragon spacecraft," NASA noted in a blog post on Tuesday. "After careful consideration, the team determined that launching Crew-10 in late March, following completion of the new Dragon spacecraft, was the best option for meeting NASA's requirements and achieving space station objectives for 2025."

The CDC has confirmed the first case of severe bird flu in the United States. NPR reports: Louisiana health officials initially reported the infection last week, saying a person was hospitalized after being exposed to sick and dead birds in backyard flocks. On Wednesday, the Centers for Disease Control and Prevention shared their findings that indicate the H5N1 virus responsible for the illness belongs to a genetic lineage that's circulating in wild birds and poultry -- different from what's spreading in dairy cattle and driving the majority of infections in agricultural workers.

In the U.S., more than 60 people have been infected so far, although some research suggests the official tally may be an undercount. The illnesses linked to dairy cattle have largely led to mild illnesses in humans.

The version of the virus in the Louisiana case is the so-called "D1.1 genotype." It has previously popped up in poultry workers in Washington state, who developed mild symptoms after testing positive in October. More recently, however, a teenager in British Columbia was hospitalized after contracting this D1.1 strain of the virus. Canadian health officials were unable to figure out how that person was infected. Dr. Demetre Daskalakis with the CDC, told reporters on Wednesday that bird blu has a well-established history of leading to severe illness and death. He added: "Infections without a clear source of exposure do occur, neither these cases nor the cases with known animal or animal products exposure have resulted in human to human transmission." California Gov. Gavin Newsom declared a state of emergency as the H5N1 bird flu virus moves from the Central valley to Southern California herds. The declaration will allow for a more streamlined approach among state and local agencies to tackle the virus, providing "flexibility around staffing, contracting, and other rules to support California's evolving response,'" reports the Los Angeles Times, citing a statement from Newsom's office.

"Building on California's testing and monitoring system -- the largest in the nation -- we are committed to further protecting public health, supporting our agriculture industry, and ensuring that Californians have access to accurate, up-to-date information," said Newsom in a statement. "While the risk to the public remains low, we will continue to take all necessary steps to prevent the spread of this virus."

Further reading:
US Government Orders Nationwide Testing of Milk for Bird Flu to Stop the Virus's Spread
Bird Flu Fears Stoke the Race for an mRNA Flu Vaccine

Scripps Research scientists sent stem-cell-derived brain organoids to the ISS to study the effects of microgravity on brain cells, finding that the organoids matured faster and showed signs of specialization compared to Earth-grown controls. The findings have been published in the journal Stem Cells Translational Medicine. Phys.Org reports: To examine how the space environment impacts cellular functions, the team compared the cells' RNA expression patterns -- a measure of gene activity -- to identical "ground control" organoids that had remained on Earth. Surprisingly, they found that the organoids grown in microgravity had higher levels of genes associated with maturity and lower levels of genes associated with proliferation compared to the ground controls, meaning that the cells exposed to microgravity developed faster and replicated less than those on Earth. "We discovered that in both types of organoids, the gene expression profile was characteristic of an older stage of development than the ones that were on the ground," [says co-senior author Jeanne Loring, Ph.D., professor emeritus in the Department of Molecular Medicine and founding director of the Center for Regenerative Medicine at Scripps Research]. "In microgravity, they developed faster, but it's really important to know these were not adult neurons, so this doesn't tell us anything about aging."

The team also noted that contrary to their hypothesis, there was less inflammation and lower expression of stress-related genes in organoids grown in microgravity, but more research is needed to determine why. Loring speculates that microgravity conditions may more closely mirror the conditions experienced by cells within the brain compared to organoids grown under conventional lab conditions and in the presence of gravity. "The characteristics of microgravity are probably also at work in people's brains, because there's no convection in microgravity -- in other words, things don't move," says Loring. "I think that in space, these organoids are more like the brain because they're not getting flushed with a whole bunch of culture medium or oxygen. They're very independent; they form something like a brainlet, a microcosm of the brain." "The next thing we plan to do is to study the part of the brain that's most affected by Alzheimer's disease," says Loring. "We also want to know whether there are differences in the way neurons connect with each other in space. With these kinds of studies, you can't rely on earlier work to predict what the result would be because there is no earlier work. We're on the ground floor, so to speak; in the sky, but on the ground floor."

SpaceX has filed a petition to incorporate its Starbase facility in South Texas as a new city, aiming to streamline infrastructure development and support the growing workforce needed for Starship production and testing. Space.com reports: "To continue growing the workforce necessary to rapidly develop and manufacture Starship, we need the ability to grow Starbase as a community," SpaceX said in the petition, which was shared in a post on X (formally Twitter). "That is why we are requesting that Cameron County call an election to enable the incorporation of Starbase as the newest city in the Rio Grande Valley."

The petition was addressed to Cameron County Judge Eddie Trevino Jr., the county's top elected official. The next step will be for officials to review the petition to determine if it complies with statutory requirements. Then, an election would be held to incorporate Starbase. [...] With Starship expected to "fundamentally alter humanity's access to space," SpaceX aims to make the area of the Starbase launch site the "Gateway to Mars," the company wrote in the petition. [...] "Incorporating Starbase will streamline the processes required to build the amenities necessary to make the area a world class place to live -- for hundreds already calling it home, as well as for prospective workers eager to help build humanity's future in space," SpaceX officials said in the petition.

An Alabama woman became the third person to receive a pig kidney transplant, doctors at NYU Langone Health announced Tuesday. Towana Looney, 53, underwent the procedure on November 25 and was discharged December 6.

Her kidney came from a pig with 10 genetic modifications designed to prevent organ rejection. The surgery follows two previous pig kidney transplants this year -- Richard Slayman at Massachusetts General Hospital, who died two months post-surgery from cardiac complications, and Lisa Pisano at NYU Langone, whose transplanted kidney was removed after 47 days due to blood flow issues.

Ars Technica's Beth Mole reports: Editors of the environmental chemistry journal Chemosphere have posted an eye-catching correction to a study reporting toxic flame retardants from electronics wind up in some household products made of black plastic, including kitchen utensils. The study sparked a flurry of media reports a few weeks ago that urgently implored people to ditch their kitchen spatulas and spoons. Wirecutter even offered a buying guide for what to replace them with. The correction, posted Sunday, will likely take some heat off the beleaguered utensils. The authors made a math error that put the estimated risk from kitchen utensils off by an order of magnitude.

Specifically, the authors estimated that if a kitchen utensil contained middling levels of a key toxic flame retardant (BDE-209), the utensil would transfer 34,700 nanograms of the contaminant a day based on regular use while cooking and serving hot food. The authors then compared that estimate to a reference level of BDE-209 considered safe by the Environmental Protection Agency. The EPA's safe level is 7,000 ng -- per kilogram of body weight -- per day, and the authors used 60 kg as the adult weight (about 132 pounds) for their estimate. So, the safe EPA limit would be 7,000 multiplied by 60, yielding 420,000 ng per day. That's 12 times more than the estimated exposure of 34,700 ng per day. However, the authors missed a zero and reported the EPA's safe limit as 42,000 ng per day for a 60 kg adult. The error made it seem like the estimated exposure was nearly at the safe limit, even though it was actually less than a tenth of the limit. "We regret this error and have updated it in our manuscript," the authors said in a correction.

"This calculation error does not affect the overall conclusion of the paper," the correction reads. The study maintains that flame retardants "significantly contaminate" the plastic products, which have "high exposure potential."

Does space need environmentalists, asks the headline from a new article in Noema magazine. "As astrophysicist Neil deGrasse Tyson notes, the first trillionaire will be made in space.

"But amid such promising developments are worries among some scientists and environmentalists who fear humans will repeat the errors that resource extraction has wrought on Earth..." If we have mining in space, do we need a preemptive anti-mining campaign to protect our solar system from rampant exploitation before it is too late? Earth-bound environmental advocates and astrobiologists alike have concluded that, indeed, we need an environmental movement in space... [Daniel Capper, an adjunct professor of philosophy at the Metropolitan State University of Denver] is part of a small but growing chorus of intellectuals who argue that we must carve out protections sooner rather than later — backed by a concrete theoretical and legal framework — for certain areas of the solar system. The United Nations has convened a working group on the use of space resources, and the International Astronomical Union has set up a different working group to delineate places of special scientific value on the moon.

Some researchers have proposed creating a planetary park system in space, while others advocate for a circular space economy that minimizes the need for additional resources. The nonprofit For All Moonkind is advocating for the protection of space sites of cultural importance, like the Apollo 11 landing site. And the Astra Carta, backed by Britain's King Charles, advocates for making sustainability a key component of space activities... [Martin Elvis, an astronomer with the Center for Astrophysics at Harvard University and the Smithsonian Institution] proposed setting aside 7/8ths of the solar system as wilderness, in a paper published in 2019 in Acta Astronautica that he coauthored with King's College London philosopher Tony Milligan...

[T]he lack of norms — clear rules and regulations around space — is one of the most pressing threats to the space environment, advocates say. What might happen, for example, if the United States simply began scooping up asteroids for platinum, or if Blue Origin established a mine at the lunar South Pole without securing consensus from others? "We do not have good answers to those questions right now," Hanlon said. "This is something that I'm really concerned about." Much of the legal basis for the space environmentalism movement is currently contained in just one article of the Outer Space Treaty (OST), said Christopher Johnson, the director of legal affairs and space law at the Secure World Foundation. Article 9 of the OST contains the harmful contamination language and says actors must pay "due regard" to the interests of others. It also stipulates that "harmful interference" with the activities of others must be avoided. Those phrases could be interpreted in multiple ways and have yet to be meaningfully tested.
The article cites two concrete proposals moving forward:

• "The Artemis Accords, a set of principles for exploring and using resources in outer space established by the U.S. in 2020, argues that resource extraction does not constitute national appropriation, and is therefore allowed by the OST. It's an initial step toward securing a consensus on space regulations, and one that's to date received the signatures of 47 nations including Japan, the United Kingdom, France and Germany (though China and Russia are notably absent). Signing the Artemis Accords allows nations to participate in the Artemis program, and also play a role in shaping future norms in space, Johnson said, a potentially lucrative incentive... "

• "The UN's COPUOS, the same one responsible for the OST and the Moon Agreement, published a working paper in 2019 that laid out voluntary guidelines for the long-term sustainability of outer space activities. Recommendations from the committee's working group on principles for the use of space resources are due in 2027, and Johnson said draft guidelines are likely to emerge in early 2025."

"One day, our descendants might live among the stars," the article concludes. "But we must ask ourselves, what kind of place will they inherit?"

Researchers used Canada's national synchrotron light source facility "to analyze a new type of lithium-ion battery material — called a single-crystal electrode — that's been charging and discharging non-stop in a Halifax lab for more than six years," reports Tech Xplore.

The results? The battery material "lasted more than 20,000 cycles before it hit the 80% capacity cutoff," which they say is equivalent to driving 8 million kms (nearly 5 million miles). That's more than eight times the life of a regular lithium-ion battery that lasted 2,400 cycles before reaching the 80% cutoff — and "When the researchers looked at the single crystal electrode battery, they saw next to no evidence of this mechanical stress." (One says the material "looked very much like a brand-new cell." Toby Bond [a senior scientist at the CLS, who conducted the research for his Ph.D.] attributes the near absence of degradation in the new style battery to the difference in the shape and behavior of the particles that make up the battery electrodes... The single crystal is, as its name implies, one big crystal: it's more like an ice cube. "If you have a snowball in one hand, and an ice cube in the other, it's a lot easier to crush the snowball," says Bond. "The ice cube is much more resistant to mechanical stress and strain." While researchers have for some time known that this new battery type resists the micro cracking that lithium-ion batteries are so susceptible to, this is the first time anyone has studied a cell that's been cycled for so long...

Bond says what's most exciting about the research is that it suggests we may be near the point where the battery is no longer the limiting component in an EV — as it may outlast the other parts of the car. The new batteries are already being produced commercially, says Bond, and their use should ramp up significantly within the next couple of years. "I think work like this just helps underscore how reliable they are, and it should help companies that are manufacturing and using these batteries to plan for the long term."
Thanks to long-time Slashdot reader schwit1 for sharing the news.

Long-time Slashdot reader smooth wombat writes: Scientist have unlocked the secret to a bacteria dubbed 'Conan the Bacterium' which is listed in the Guinness Book of World Records as the most radiant-resistant life-form. Deinococcus radiodurans can withstand radiation doses 28,000 times greater than that which would kill a human [and every other organism]. In addition, this bacteria can survive on the outside of the International Space Station for three years. It can also withstand acid, cold, and dehydration (a D&D player's worst nightmare). All of this protection comes down to a unique antioxidant.

The antioxidant is formed by a simple group of small molecules called metabolites, including manganese, phosphate and a small peptide, or molecule, of amino acids.
CNN reports: The antioxidant is formed by a simple group of small molecules called metabolites, including manganese, phosphate and a small peptide, or molecule, of amino acids. Together, this powerful trilogy is more effective in protecting against radiation than manganese combined with just one of the other components, according to a new study published Monday in the Proceedings of the National Academy of Sciences.

The findings could be used to protect astronauts from high doses of cosmic radiation on future deep-space missions across our solar system, according to the study authors.

"We've long known that manganese ions and phosphate together make a strong antioxidant, but discovering and understanding the 'magic' potency provided by the addition of the third component is a breakthrough," said study coauthor Brian Hoffman, the Charles E. and Emma H. Morrison Professor of Chemistry and professor of molecular biosciences at Northwestern University's Weinberg College of Arts and Sciences, in a statement...

On Earth, the antioxidant could be used for protection against accidents that release radiation.

NASA believes Ingenuity's navigation system was responsible for its crash on the surface of Mars. Engineers determined that the helicopter's navigation system struggled to track features over smooth terrain, leading to a hard landing and structural failure. Universe Today reports: Now, almost a year after the incident, a team of engineers from NASA's Jet Propulsion Laboratory have been analyzing the data. Their findings will be published in the next few weeks however the team of engineers assert it was harder than expected to complete an accident investigation from 160 million kilometers. The faults lie in the navigation system that was designed to visually track surface features using a camera pointed at the round. The system worked during early flights over more textured terrain but as Ingenuity moved over the Jezero Crater, it began operating over featureless sand ripples.

The navigation system was designed to provide estimates of the helicopter's velocity, chiefly to enable it to land. The data revealed from Flight 72 revealed that the navigation system couldn't find features to track. Images showed that the lack of features led to a harder than usual touchdown leading to a pitch and roll of the craft. The sudden change of attitude led to increase load on the rotors, beyond their designed limits leading to the structural damage. "Even though Ingenuity will not be able to fly anymore it can still provide weather and avionics data to the Perseverance rover," notes Universe Today. "It will help us to understand more about the weather in its vicinity but perhaps its greatest legacy are its hours of flight on an alien world."

An anonymous reader quotes a report from Science Magazine: It would be a nightmare lab leak: Synthetic bacteria escape the petri dish and unleash a global plague that life on Earth is incapable of defending itself against. That's the concern raised by a group of eminent researchers in a Policy Forum published online today in Science. The commentary's 38 authors, from a broad range of disciplines, argue that governments worldwide should prohibit research and funding aimed at creating so-called mirror-image bacteria whose chemical makeup differs in a fundamental way from that of naturally existing organisms.

All of life's primary biomolecules can exist in two mirror-image forms, like a left and right hand. But only one form is found in nature. Proteins are left-handed, for example, and DNA and RNA are right-handed. Synthetic biologists have previously synthesized mirror-image proteins and genetic molecules. And mirror-image amino acids and peptides -- the building blocks of proteins -- have been incorporated into several approved drugs. Because natural enzymes struggle to break down mirror-image biomolecules, these components help the drugs survive longer in the body. [...]

The concern, he and others say, is that taking this line of work many steps further could result in fully mirror-image bacteria that could reproduce. Such organisms would likely be able to infect and potentially harm a wide range of microbes, plants, and animals while resisting the molecules that enable predators to kill and digest existing microbes. "They are essentially unassailable to those enzymes," says John Glass, a co-author and synthetic biologist at the J. Craig Venter Institute. Animals' immune systems would also struggle to cope with mirror bacteria. They "would be invisible to the immune system until it was too late," says Timothy Hand, a co-author and immunologist at the University of Pittsburgh. The Policy Forum authors acknowledge it will be at least a decade before synthetic biologists will be capable of creating these life forms. Nevertheless, they recommend halting all research aimed at that goal and urge funding agencies not to support it. "It's hard to overstate how severe these risks could be," says Ruslan Medzhitov, an immunologist at Yale University and one of the authors. "If mirror bacteria were to spread through infected animals and plants, much of the planet's many environments could be contaminated. ... Any exposure to contaminated dust or soil could be fatal."

Jack Szostak, a co-author and a 2019 Nobel Prize-winning chemist at the University of Chicago, adds: "The result could be catastrophic irreversible damage, perhaps far worse than any challenge we've previously encountered."

In an announcement that stunned New Zealand's research community, the country's center-right coalition government said it would divert half of the NZ$75 million Marsden Fund, the nation's sole funding source for fundamental science, to "research with economic benefits." From a report: Moreover, the fund would no longer support any social sciences and humanities research, and the expert panels considering these proposals would be disbanded.

Universities New Zealand, which represents the nation's eight universities, called the planned disinvestment in social science and humanities "astonishing." It was among several academic groups and many scientists calling for the government to reverse the unexpected decision.

In announcing the change, Minister of Science, Innovation and Technology Judith Collins said the fund should focus on "core science" that supports economic growth and "a science sector that drives high-tech, high-productivity, high-value businesses and jobs."

An international research team has for the first time imaged and controlled a type of magnetic flow called altermagnetism, which physicists say could be used to develop faster and more reliable electronic devices. Financial Times: A groundbreaking experiment at a powerful X-ray microscope in Sweden provides direct proof of the existence of altermagnetism, according to a paper published in Nature on Wednesday. Altermagnetic materials can sustain magnetic activity without themselves being magnetic.

The team from the UK's Nottingham university that led the research said the discovery has revolutionary potential for the electronics industry. "Altermagnets have the potential to lead to a thousand-fold increase in the speed of microelectronic components and digital memory, while being more robust and energy-efficient," said senior author Peter Wadley, Royal Society research fellow at Nottingham.

Hard disks and other components underpinning the modern computers industry process data in ferromagnetic materials, whose intrinsic magnetism limits their speed and packing density. Using altermagnetic materials will allow current to flow in non-magnetic products.