The project was designed to pick up where the Human Genome Project left off. Although that massive effort revealed the blueprint of human biology, it quickly became clear that the instruction manual for reading the blueprint was sketchy at best. Researchers could identify in its 3 billion letters many of the regions that code for proteins, but those make up little more than 1% of the genome, contained in around 20,000 genes. ENCODE, which started in 2003, aims to catalog the ‘functional’ DNA sequences between genes, learn when and in which cells they are active and trace their effects on how the genome is packaged, regulated and read.
Nature has set up an ENCODE site with an explorer, that groups the papers by topic, and collects all the papers, which are available free."
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