The researchers coated coated iron oxide nanoparticles with antibodies that bind to a modified version of a temperature-sensitive ion channel. They injected these particles into tumors grown under the skins of mice, then heated the nanoparticles with low-frequency radio waves. The nanoparticles heated the ion channel, activating it and allowing calcium to flow into cells. The influx of calcium switched on an engineered calcium-sensitive gene that produces insulin (abstract)."
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